The First 24 Hours are Critical
Traumatic brain injured individuals need to be acutely treated within the first “golden” hour and in the first 24 hours there is a continued pressing need to reduce the release of toxic proteins which include cytokines as well as acetylated tau. This one hour window of opportunity is best be treated “on site” by a rapid intravenous injection of an agent that reduces the accumulation of neuroinflammatory cytokines as well as the toxic acetylated tau (ac-tau).
The figure on the left is from the following citation: Lucke-Wold B, Seidel K, Udo R, Omalu B, Ornstein M, Nolan R, Rosen C, Ross J. Role of Tau Acetylation in Alzheimer’s Disease and Chronic Traumatic Encephalopathy: The Way Forward for Successful Treatment. J Neurol Neurosurg. 2017;4(2):140.