The active moiety of JD-004 is effective in slowing the aging process in the animal model associated with Progeria, an accelerated aging disease of children. It is highly likely that when used in the Progeria children (also known as Hutchinson-Gilford Progeria Syndrome/HGPS), JD-004 will be successful in slowing their accelerated aging process.
Below in figure A is a photograph of a healthy mouse. In the middle photograph is a mouse with the progeria gene (note the small size and low weight). In the photograph on the right is a mouse with the progeria gene and note the significant improvement in size and weight when given the active moiety of JD-004. Figure B shows the significant increase in weight in the Progeria mouse model when given the active moiety of JD-004. Figure C shows the increase in life expectancy in the Progeria mouse model when given the active moiety of JD-004. Figure D illustrates the molecular mechanism whereby the active moiety of JD-004 extends longevity and prevents progeroid features in a Progeria mouse model (reduction in the master molecular of inflammation known as nuclear factor kappa b or NFK-b). Figure E illustrates the active moiety of JD-004 improves bone density in the mouse model of Progeria.
