Polycystic kidney disease (PKD) is a genetic disease (passed from an affected parent to their child) causing uncontrolled growth of cysts in the kidney eventually leading to kidney failure.
The only currently FDA treatment Jynarque (tolvaptan) for ADPKD is associated with severe polyuria (excessive urination, up to 2.5 gallons per day) leading to potential and severe dehydration. I safer and effective alternative is sorely needed. J & D Pharmaceuticals LLC believes it has discovered such a medication. JD-005 is derived from a natural (plant) based source and can be considered a “green molecule”. JD-005 has been shown to be as effective as Jynarque (tolvaptan) in an animal model of ADPKD. JD-005 has been safely tested in healthy volunteers and found to be very well tolerated. Clinical studies are expected to start as soon as q2025.